LORVOTUZUMAB MERTANSINE
Lorvotuzumab mertansine is an antibody drug conjugate pharmaceutical. It is currently being investigated in clinical studies. It is known to target neural cell adhesion molecule 1.
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Commercial
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | — | C34.90 | 2 | 2 | — | — | — | 2 |
| Small cell lung carcinoma | D055752 | — | — | 2 | 2 | — | — | — | 2 |
| Neuroblastoma | D009447 | EFO_0000621 | — | — | 1 | — | — | — | 1 |
| Synovial sarcoma | D013584 | — | — | — | 1 | — | — | — | 1 |
| Rhabdomyosarcoma | D012208 | — | — | — | 1 | — | — | — | 1 |
| Neurofibrosarcoma | D018319 | — | — | — | 1 | — | — | — | 1 |
| Wilms tumor | D009396 | EFO_0000212 | — | — | 1 | — | — | — | 1 |
| Pulmonary blastoma | D018202 | — | — | — | 1 | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 2 | — | — | — | — | 2 |
| Recurrence | D012008 | — | — | 1 | — | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Merkel cell carcinoma | D015266 | EFO_1001471 | C4A | 1 | — | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LORVOTUZUMAB MERTANSINE |
| INN | lorvotuzumab mertansine |
| Description | Lorvotuzumab Mertansine (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies; maytansinoid derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743037 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 0IVD6ASY0W (ChemIDplus, GSRS) |
Target
Agency Approved
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NCAM1
NCAM1
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Trends
PubMed Central
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Additional graphs summarizing 276 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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11 adverse events reported
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